Synthesis, Characterization and Pharmacological Evaluation of N-Substituted Derivatives of 5-(4-Nitrophenyl)-1, 3, 4-oxadiazole-2yl-2"-sulphanyl Acetamide

…, K Nafeesa, A Malik, M Ashraf, T Ismail…

Index: Gul, Samreen; Ur-Rehman, Aziz; Abbasi, Muhammad Athar; Nafeesa, Khadija; Malik, Abdul; Ashraf, Muhammad; Ismail, Tayaba; Ahmad, Irshad Asian Journal of Chemistry, 2013 , vol. 25, # 11 p. 6231 - 6236

Full Text: HTML

Citation Number: 3

Abstract

Abstract A series of new N-substituted 5-(4-nitrophenyl)-1, 3, 4-oxadiazole-2-yl-2"-sulphanyl acetamides was synthesized and enzyme inhibiting activity was screened for all these chemical entities. Structural characterization of all these compounds was made by IR, EI-MS and 1H NMR. All derivatives demonstrated different extent of activity for lipoxygenase (LOX), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Compounds 6j exhibited ...

Related Articles:

Push–Pull Azo??Chromophores Containing Two Fused Pentatomic Heterocycles and Their Nonlinear Optical Properties

[Centore, Roberto; Fusco, Sandra; Peluso, Andrea; Capobianco, Amedeo; Stolte, Matthias; Archetti, Graziano; Kuball, Hans-Georg European Journal of Organic Chemistry, 2009 , # 21 p. 3535 - 3543]

Synthesis of some novel 3, 5-disubstituted 1, 3, 4-oxadiazole derivatives and anticancer activity on EAC animal model

[Dash, Sasmita; Kumar, B. Ashok; Singh, Jagadish; Maiti; Maity Medicinal Chemistry Research, 2011 , vol. 20, # 8 p. 1206 - 1213]

Synthesis of some novel 3, 5-disubstituted 1, 3, 4-oxadiazole derivatives and anticancer activity on EAC animal model

[Dash, Sasmita; Kumar, B. Ashok; Singh, Jagadish; Maiti; Maity Medicinal Chemistry Research, 2011 , vol. 20, # 8 p. 1206 - 1213]

Synthesis and evaluation of novel azoles as potent antifungal agents

[Li, Liangjing; Ding, Hao; Wang, Baogang; Yu, Shichong; Zou, Yan; Chai, Xiaoyun; Wu, Qiuye Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 192 - 194]

Synthesis and evaluation of novel azoles as potent antifungal agents

[Li, Liangjing; Ding, Hao; Wang, Baogang; Yu, Shichong; Zou, Yan; Chai, Xiaoyun; Wu, Qiuye Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 192 - 194]

More Articles...