Smooth and selective formation of the cyclic 1, N 2-propano adducts in the reactions of guanine nucleosides and nucleotides with acetaldehyde

M Sako, I Yaekura, Y Deyashiki

Index: Sako, Magoichi; Yaekura, Isamu; Deyashiki, Yoshihiro Tetrahedron Letters, 2002 , vol. 43, # 38 p. 6701 - 6703

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Citation Number: 11

Abstract

The treatment of guanine nucleosides and nucleotides with excess acetaldehyde in pH 8.0 phosphate buffer containing a basic amino acid such as arginine and lysine resulted in the smooth and selective formation of the corresponding cyclic 1, N2-propano adducts even under mild conditions.