Vilsmeier Reaction of Methylpyrazine

HV Hansen, JA Caputo, RI Meltzer

Index: Hansen,H.V. et al. Journal of Organic Chemistry, 1966 , vol. 31, p. 3845 - 3847

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Citation Number: 8

Abstract

The Vilsmeier adduct (11) proved to be a versatile intermediate for the preparation of heterocycles substituted with a pyrazine ring. Thus, condensation with the carbonyl reagents hydroxylamine and phenylhydrazine furnished the isoxaaole (IVa) and pyrazole (IVb), respectively. Similarly, reaction with urea derivatives or amidines gave the 5-(2-pyraainyl)- pyrimidines (Va-c).