Synthesis of Chiral Cyclobutane Containing C 3-Symmetric Peptide Dendrimers†

R Gutiérrez-Abad, O Illa, RM Ortuno

Index: Gutierrez-Abad, Raquel; Illa, Ona; Ortuno, Rosa M. Organic Letters, 2010 , vol. 12, # 14 p. 3148 - 3151

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Citation Number: 25

Abstract

Five new highly functionalized cyclobutane containing C 3-symmetric peptide dendrimers have been synthesized through a convergent approach from 1, 3, 5-trisubstituted benzene and chiral γ, ε-amino diacid derivatives as well as a γ-tetrapeptide. The first example of the synthesis of N-centered amides by using 1, 3, 5-triaminobenzene and a carboxylic acid is reported.