Synthesis of 2-alkenyl-1-pyrrolin-1-oxides and polysubstituted nitrones

CP Sar, J Jekő, K Hideg

Index: Sar, Cecilia; Jeko, Jozsef; Hideg, Kalman Synthesis, 2003 , # 9 p. 1367 - 1372

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Citation Number: 6

Abstract

Abstract A new approach for the synthesis of α-hydroxy nitroxide ester 4 by oxidation of the sterically hindered amine 3 is described. The reaction of 2-methyl-1-pyrrolin-1-oxides 1 and 7 with aldehydes 5a-j gave 2-alkenyl nitrones, which could be converted to higher methylated 2-alkenyl DMPO type nitrones 11d or pyrrolidine nitroxides 12b, c, d, g, h, i with MeMgI.