Synthesis and psychotropic properties of 4-amino-3-cyano-1, 2-dihydrospiro (naphthalene-2, 1'cyclopentane) derivatives

AI Markosyan, MG Oganisyan, RA Kuroyan…

Index: Markosyan, A. I.; Oganisyan, M. G.; Kuroyan, R. A.; Sukasyan, R. S.; Arzanunts, E. M.; Sarkisyan, I S. Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 8 p. 536 - 539 Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 8 p. 26 - 28

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Citation Number: 12

Abstract

By condensation of aminonitrile II with benzaldehyde and orthoformic ester, the Schiff base III and the ethoxymethylene compound IV were obtained. Bromination of aminonitrile II in glacial acetic acid and subsequent treatment with a base gave 3-bromo-4-oxo-3-cyano-1, 2, 3, 4-tetrahydrospiro (naphthalene-2, 1'-cyclopentane)(V). the reaction of aminonitrile II with carboxylic acid chlorides was studied and the following patterns were discovered. The ...