Design and Synthesis of 1??(6??(2??(2??Arylethynyl) Phenyl) Hexyn??5??yl) Piperidin??2??Ones as Antitumor Agents that Induce Apoptotic Progress

I Lin, I Chen, CF Lin, YH Lo, SH Yang…

Index: Lin, I.-Ling; Chen, I.-Hsiang; Lin, Chi-Fong; Lo, Yu-Hsiang; Yang, Sheng-Huei; Lin, Shinne-Ren; Wu, Ming-Jung Journal of the Chinese Chemical Society, 2008 , vol. 55, # 3 p. 668 - 674

Full Text: HTML

Citation Number: 2

Abstract

Abstract A series of 1-(6-(2-(2-arylethynyl) phenyl) hexyn-5-yl) piperidin-2-ones 2a-j were synthesized and their antitumor activities were evaluated. Of these compounds, 1-(6-(2-(2-(4- nitrophenyl) ethynyl) phenyl) hexyn-5-yl) piperidin-2-one (2j) showed the highest potency of growth inhibition activity, especially against the RPMI-8226 (0.4 μM) and SR (0.02 μM) cell lines of human leukemia. Compound 2j also induced significant apoptotic progress in the ...

Related Articles:

Catalytic generation of arynes and trapping by nucleophilic addition and iodination

[Hamura, Toshiyuki; Chuda, Yu; Nakatsuji, Yuya; Suzuki, Keisuke Angewandte Chemie - International Edition, 2012 , vol. 51, # 14 p. 3368 - 3372]

Selective and efficient access to ortho, meta and para ring-substituted phenylacetylene derivatives R-[C CC 6 H 4] xY (Y: H, NO 2, CN, I, NH 2)

[Lavastre, Olivier; Cabioch, Sandrine; Dixneuf, Pierre H.; Vohlidal, Jiri Tetrahedron, 1997 , vol. 53, # 22 p. 7595 - 7604]

Efficient synthesis of a complete donor/acceptor bis (aryl) diyne family

[Holmes, Brian T.; Pennington, William T.; Hanks, Timothy W. Synthetic Communications, 2003 , vol. 33, # 14 p. 2447 - 2461]

More Articles...