An efficient route towards the synthesis of monosubstituted N-aryl amidines from 4, 5-dihydro-1, 2, 4-oxadiazoles

NL Chavan, NH Naik, SK Nayak, RS Kusurkar

Index: Chavan, Neelam L.; Naik, Nilesh H.; Nayak, Sandip K.; Kusurkar, Radhika S. Arkivoc, 2010 , vol. 2010, # 2 p. 248 - 255

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Citation Number: 2

Abstract

Abstract 4, 5-Dihydro-1, 2, 4-oxadiazoles were prepared using 1, 3-dipolar cycloaddition of imines with nitrile oxides. Further reductive NO bond cleavage furnished monosubstituted N- aryl amidines in good yield. Thus an efficient route for the synthesis of monosubstituted N- aryl amidines has been developed. Keywords: N-aryl amidines, 4, 5-dihydro-1, 2, 4- oxadiazoles, hydrogenolysis, Nitrile oxides, 1, 3-dipolar cycloaddition reaction