Semisynthetic maytansine analogues for the targeted treatment of cancer

WC Widdison, SD Wilhelm, EE Cavanagh…

Index: Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4392 - 4408

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Citation Number: 204

Abstract

... Journal of Medicinal Chemistry. ... The chemistry followed the scheme originally designed by Kupchan at al., 5,15 who first reported the chemical conversion of maytansine to the C3 hydroxy compound, maytansinol, and its subsequent conversion to different C3 esters. ...