Organic letters

Domino N− H/C− H Bond Activation: Copper-Catalyzed Synthesis of Nitrogen-Bridgehead Heterocycles Using Azoles and 1, 4-Dihalo-1, 3-dienes

Q Liao, L Zhang, S Li, C Xi

Index: Liao, Qian; Zhang, Liyun; Li, Shutao; Xi, Chanjuan Organic Letters, 2011 , vol. 13, # 2 p. 228 - 231

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Citation Number: 54

Abstract

Copper-catalyzed tandem coupling of 1, 4-dihalo-1, 3-dienes with azoles via an N− H bond and its adjacent C− H bond activation has been described. The reaction exhibits good regioselectivity when unsymmetrical 1, 4-dihalo-1, 3-diene is employed. This method provided a novel route to the synthesis of nitrogen-bridgehead azolopyridine derivatives.

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