Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl) adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive …

…, T Murayama, Y Nomura, A Matsuda

Index: Homma, Hiroshi; Watanabe, Yohko; Abiru, Toichi; Murayama, Toshihiko; Nomura, Yasuharu; Matsuda, Akira Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2881 - 2890

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Citation Number: 65

Abstract

adenosines have (L pdaiad A2 adezuwiae reaptor selectivity in rat brain.” Frorn studies of the & “-activity relationships, an acetylenic functional group at the C-2 position of adenosine was essential for having affinities to both receptors, and the length of the alkyl side chain attached to the ethynyl group influenced either binding affinity or receptor selectivity. Of a series of 2-alkynyladenosines, 2-(l-hexyn-l-yl) adenosine (7) shed the most potent A, ...