Biosynthesis of the hemlock alkaloids. The incorporation of acetate-1-C14 into coniine and conhydrine

E Leete

Index: Leete,E. Journal of the American Chemical Society, 1964 , vol. 86, p. 2509 - 2513

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Citation Number: 38

Abstract

The biosynthesis of the alkaloids of Conium maculatum (hemlock) has been studied using C14-labeled compounds. The alkaloids obtained from hemlock plants which had been fed DL-lysine-2-C'“or~ adaverine-l, 5-C'~ had negligible activity. On the other hand, the administration of sodium acetate-l-C14 to the plants led to the formation of radioactive coniine and conhydrine. A systematic degradation of the coniine established that almost ...