Synthesis and SAR of adatanserin: novel adamantyl aryl-and heteroarylpiperazines with dual serotonin 5-HT1A and 5-HT2 activity as potential anxiolytic and …

MA Abou-Gharbia, WE Childers…

Index: Boksa; Misztal; Chojnacka-Wojcik; Gastol-Lewinska; Grodecka; Mokrosz Pharmazie, 1992 , vol. 47, # 4 p. 254 - 257

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Citation Number: 83

Abstract

... Volume: Page: ... Cbz for 24 and 28; (i) (EtO) 2 P(O)CN, N-methylmorpholine, HCl/EtOAc for R = BOC, 30% aq HBr for R = Cbz ... a Reagents and conditions: method L − (i) N-benzylpiperazine; (ii) LiAlH 4 ; (iii) adamantane-1-carboxylic acid chloride, Et 3 N; (iv) H 2 ...