Microwave-assisted minutes synthesis of bioactive phenylbutanoids occurring in Zingiber cassumunar

BP Joshi, NP Singh, A Sharma, AK Sinha

Index: Joshi; Singh; Sharma; Sinha Chemistry of Natural Compounds, 2005 , vol. 41, # 4 p. 370 - 373

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Citation Number: 6

Abstract

Abstract Microwave-assisted condensation of benzaldehyde (3a, b) with acetone in aqueous sodium hydroxide adsorbed on basic alumina provides phenylbutenone (4a–4b) in 68–71% yield within 4 min, which upon further reduction with sodium borohydride and basic alumina gives phenylbutenol (5a, b) in 91–94% yield within 2 min. Dehydration of 5 with anhydrous copper (II) sulfate gives phenylbutadiene (1a, b), a metabolite of Zingiber cassumunar, ...