Journal of heterocyclic chemistry

Preparation of benzo [c][2, 7] naphthyridines

CF Nutaitis, SR Marsh

Index: Nutaitis, Charles F.; Marsh, Stephen R. Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 971 - 973

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Citation Number: 6

Abstract

Abstract A divergent synthesis of substituted benzo [c][2, 7] naphthyridines 5a-h is described, which features an intramolecular pyridyne cyclization step as the key reaction. The pyridyne precursors are conveniently prepared from the pyridinium hydrochloride 2 and the requisite anilines. Cyclization of the non-symmetric substrates 3e and 3f did not proceed with significant regioselectivity.