Studies on pyrazine. 23. Homolytic acylation of 2??amino??3??cyanopyrazine and the related compounds with α??keto acids: A synthesis of 5??acyl??3?? …

N Sato, H Kadota

Index: Sato, Nobuhiro; Kadota, Hisashi Journal of Heterocyclic Chemistry, 1992 , vol. 29, p. 1685 - 1688

Full Text: HTML

Citation Number: 11

Abstract

Abstract Homolytic acylation of 2-amino-3-cyanopyrazine (1) with α-keto acids led to the formation of 6-acylated compounds in 74-85% yields. Methyl 3-aminopyrazinecarboxylate (2) and 3-aminopyrazinecarboxamide (3) were also acylated under the same conditions although in lower yields. The observed reactivity of acylation is explained by comparison with the homolytic reactions of related pyrazines.