Synthesis and structure–activity relationship studies in translocator protein ligands based on a pyrazolo [3, 4-b] quinoline scaffold

…, S Valenti, G Giuliani, M Paolino, M Anzini…

Index: Cappelli, Andrea; Bini, Giulia; Valenti, Salvatore; Giuliani, Germano; Paolino, Marco; Anzini, Maurizio; Vomero, Salvatore; Giorgi, Gianluca; Giordani, Antonio; Stasi, Luigi Piero; Makovec, Francesco; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Concas, Alessandra; Porcu, Patrizia; Biggio, Giovanni Journal of Medicinal Chemistry, 2011 , vol. 54, # 20 p. 7165 - 7175

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Citation Number: 8

Abstract

As a further development of our large program focused on the medicinal chemistry of translocator protein [TSPO (18 kDa)] ligands, a new class of compounds related to alpidem has been designed using SSR180575, emapunil, and previously published pyrrolo [3, 4-b] quinoline derivatives 9 as templates. The designed compounds were synthesized by alkylation of the easily accessible 4-methyl-2-phenyl-1 H-pyrazolo [3, 4-b] quinolin-3 (2 H) ...