Unsymmetrically Substituted Furoxans, XIV. Synthesis and Structure of a Trimer of the Furoxan System with High Vasodilator and Platelet Antiaggregatory Activity

…, A Di Stilo, R Fruttero, G Sorba, A Gasco…

Index: Gasco, Andrea Marcello; Stilo, Antonella Di; Fruttero, Roberta; Sorba, Giovanni; Gasco, Alberto; Sabatino, Piera Liebigs Annalen der Chemie, 1993 , # 4 p. 441 - 444

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Abstract

Abstract The synthesis and structure of a trimer 5 of the furoxan system are reported. The probable origin of this derivative is the dimerization of the intermediate 4-phenyl-3- furoxancarbonitrile oxide (4) obtained by decomposition of the corresponding nitrolic acid 3. The title compound shows a high level of activity as vasodilator and inhibitor of platelet aggregation.