Novel desosamine-modified 14-and 15-membered macrolides without antibacterial activity

…, D Pešić, I Vujasinović, S Alihodžić, HČ Paljetak…

Index: Jakopovic, Ivana Palej; Krajacic, Mirjana Bukvic; Skugor, Maja Matanovic; Stimac, Vlado; Pesic, Dijana; Vujasinovic, Ines; Alihodzic, Sulejman; Paljetak, Hana Cipcic; Kragol, Goran Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3527 - 3530

Full Text: HTML

Citation Number: 8

Abstract

Novel modifications of the desosamine sugar of 14-and 15-membered antibacterial macrolides, in which the desosamine was fused with N-substituted-1, 3-oxazolidin-2-ones, were developed in order to completely suppress antibacterial activity and make them promising agents for other biological targets. The synthesis of such bicyclic desosamine derivatives, especially 1, 3-oxazolidin-2-one formation, was optimized and conducted ...