Synthesis of 3-[(N-carboalkoxy) ethylamino]-indazole-dione derivatives and their biological activities on human liver carbonyl reductase

…, C Luster, HA Charlier, DL Warner, LH Zalkow…

Index: Berhe, Solomon; Slupe, Andrew; Luster, Choice; Charlier Jr., Henry A.; Warner, Don L.; Zalkow, Leon H.; Burgess, Edward M.; Enwerem, Nkechi M.; Bakare, Oladapo Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 1 p. 134 - 141

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Citation Number: 16

Abstract

A series of indazole-dione derivatives were synthesized by the 1, 3-dipolar cycloaddition reaction of appropriate substituted benzoquinones or naphthoquinones and N- carboalkoxyamino diazopropane derivatives. These compounds were evaluated for their effects on human carbonyl reductase. Several of the analogs were found to serve as substrates for carbonyl reductase with a wide range of catalytic efficiencies, while four ...