An efficient synthesis of 2-amino alcohols by silica gel catalysed opening of epoxide rings by amines

AK Chakraborti, S Rudrawar…

Index: Chakraborti, Asit K.; Rudrawar, Santosh; Kondaskar, Atul Organic and Biomolecular Chemistry, 2004 , vol. 2, # 9 p. 1277 - 1280

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Citation Number: 94

Abstract

Silica gel (60–120 mesh) efficiently catalyses the opening of epoxide rings by amines at rt under solvent-free conditions providing an easy method for the synthesis of 2-amino alcohols. Aromatic and aliphatic amines react with cyclohexene oxide with exclusive formation of the trans-2-aryl/alkylaminocyclohexanols in high yields. A complementary regioselectivity is exhibited by aromatic and aliphatic amines during the reaction with ...