Potential nootropic agents: synthesis of a series of (2-oxo-1-pyrrolidinyl) acetic acid piperazides

V Valenta, K Šindelář, J Holubek…

Index: Valenta, Vladimir; Sindelar, Karel; Holubek, Jiri; Ryska, Miroslav Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 6 p. 1613 - 1629

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Citation Number: 8

Abstract

Abstract The title compounds VI-XXIII were prepared by heating ethyl (2-oxo-1-pyrrolidinyl) acetate (II) with a series of N-monosubstituted piperazines. The propionamides XXVI and XXX were obtained by reactions of the acid chlorides IV and XXXIII with 3-(1-piperazinyl) propionamide. Compounds VI (V⁄ FB-13 763) and VIII (V⁄ FB-14 745) proved more active than piracetam (I) by their antiamnesic effects in rats, by antagonizing the brain-damaging ...