Preorganization in bistriazolyl anion receptors
T Merckx, P Verwilst, W Dehaen
Index: Merckx, Tamara; Verwilst, Peter; Dehaen, Wim Tetrahedron Letters, 2013 , vol. 54, # 32 p. 4237 - 4240
Full Text: HTML
Citation Number: 17
Abstract
A series of 4, 6-bis-(1, 2, 3-triazolyl)-pyrimidine and 4, 6-bis-(1, 2, 3-triazolyl)-pyridine anion receptors were synthesized and the effect of the pyrimidine and pyridine moieties on their binding properties was examined. We found that intramolecular interactions preorganize the 4, 6-bis-(1, 2, 3-triazolyl)-pyridine receptors resulting in higher anion binding constants in comparison with the nonpreorganized 4, 6-bis-(1, 2, 3-triazolyl)-pyrimidine receptor.
Related Articles:
[Sasse, Astrid; Stark, Holger; Reidemeister, Sibylle; Huels, Annette; Elz, Sigurd; Ligneau, Xavier; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4269 - 4274]
[Mueller,G.; Merten,R. Chemische Berichte, 1965 , vol. 98, p. 1097 - 1110]
[Hayman,D.F. et al. Journal of Pharmacy and Pharmacology, 1964 , vol. 16, p. 538 - 548]