A general method for the synthesis of aryl [11 C] methylsulfones: potential PET probes for imaging cyclooxygenase-2 expression

…, J Prabhakaran, NR Simpson, RL Van Heertum…

Index: Majo, Vattoly J.; Prabhakaran, Jaya; Simpson, Norman R.; Van Heertum, Ronald L.; Mann, J. John; Kumar, J. S. Dileep Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4268 - 4271

Full Text: HTML

Citation Number: 38

Abstract

A general one-pot method has been developed for the conversion of an aryl thiol moiety masked as the butyrate ester to the corresponding 11C-labeled methylsulfone group. The potential of this methodology has been demonstrated by the successful radiosynthesis of carbon-11 analogues of several highly selective cyclooxygenase-2 (COX-2) inhibitors such as Rofecoxib, Etoricoxib, and 3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethyl ...

Related Articles:

Mucochloric Acid: A Useful Synthon for the Selective Synthesis of 4??Aryl??3??chloro??2 (5H)??furanones,(Z)??4??Aryl??5??[1??(aryl) methylidene]??3??chloro??2 (5H)??furanones …

[Bellina, Fabio; Anselmi, Chiara; Martina, Francesca; Rossi, Renzo European Journal of Organic Chemistry, 2003 , # 12 p. 2290 - 2302]

Mucochloric Acid: A Useful Synthon for the Selective Synthesis of 4??Aryl??3??chloro??2 (5H)??furanones,(Z)??4??Aryl??5??[1??(aryl) methylidene]??3??chloro??2 (5H)??furanones …

[Bellina, Fabio; Anselmi, Chiara; Martina, Francesca; Rossi, Renzo European Journal of Organic Chemistry, 2003 , # 12 p. 2290 - 2302]

Magnesium mediated carbometallation of propargyl alcohols: direct routes to furans and furanones

[Forgione, Pat; Wilson, Peter D.; Fallis, Alex G. Tetrahedron Letters, 2000 , vol. 41, # 1 p. 17 - 20]

More Articles...