Tetrahedron letters

An efficient, regioselective and fast enzymatic glycosylation for cyclodextrins

V Bonnet, C Boyer, V Langlois, R Duval, C Rabiller

Index: Bonnet, Veronique; Boyer, Christophe; Langlois, Virginie; Duval, Raphael; Rabiller, Claude Tetrahedron Letters, 2003 , vol. 44, # 50 p. 8987 - 8989

Full Text: HTML

Citation Number: 9

Abstract

The introduction of a short spacer arm was necessary to obtain complete regioselectivity in the glycosylation of β-cyclodextrin (β-CD) mediated by glycosidases. Thus 6-N-(2- aminoethyl-α-d-galactopyranosyl)-6-deoxycyclomaltoheptaose was prepared in four steps from β-cyclodextrin with 30% overall yield using, in the key step, the transfer activity of green coffee bean α-galactosidase.