An efficient synthetic method for (±)-Malyngolide and its optical resolution

K Machiya, I Ichimoto, K Tonari, M Kirihata…

Index: Machiya; Ichimoto; Tonari; et al. Agricultural and Biological Chemistry, 1985 , vol. 49, # 6 p. 1767 - 1773

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Citation Number: 7

Abstract

A convenient synthetic method for (±)-malyngolide (1), an antibiotic from the marine bluegreen alga Lyngbya majuscula GOMONT, is described. The compound (±)-1 was synthesized from 2-methylglutaric anhydride (starting material) in four steps, involving the TBHP-based osmium-catalyzed procedure for vicinal dihydroxylation of the methylene unit in unsaturated carboxylic acid as the key step. The optical resolution of (±)-l was ...