5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes …
P Wigerinck, C Pannecouque, R Snoeck…
Index: Wigerinck, P.; Pannecouque, C.; Snoeck, R.; Claes, P.; Clercq, E. De; Herdewijn, P. Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2383 - 2389
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Citation Number: 90
Abstract
Method B. Acetal derivative 4a (400 mg, 1.17 “01) was gently refluxed in 40% acetic acid (25 mL) with a slow distillation of solvent in order to remove ethanol formed in the reaction. During the reaction time ca. 10 mL of a distillate (bp 92-94 “C) were collected. The rest of solvent was then evaporated under diminished pressure and a resulting white residue was coevaporated twice with 2-propanol, which gave the chromatographically pure 3a as a ...
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