Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase

…, A Della Torre, F Heidempergher, P Pevarello…

Index: Varasi; Della Torre; Heidempergher; Pevarello; Speciale; Guidetti; Wells; Schwarcz European Journal of Medicinal Chemistry, 1996 , vol. 31, # 1 p. 11 - 21

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Citation Number: 22

Abstract

The structural requirements of the catalytic site of kynurenine aminotransferase (KAT), the enzyme responsible for the conversion of l-kynurenine (KYN) to kynurenic acid (KYNA), were examined using analogs and derivatives of KYN. KYNA production from KYN was monitored in rat brain homogenates and brain tissue slices. Modification of KYN's acylalanine side chain or its ring amino group resulted in compounds which did not ...