Novel cytokine production inhibitors produced by a basidiomycete, Marasmiellus sp.

K Ichikawa, H Hirai, M Ishiguro, T Kambara…

Index: Ichikawa; Hirai; Ishiguro; Kambara; Kato; Kim; Kojima; Matsunaga; Nishida; Shiomi; Yoshikawa Journal of Antibiotics, 2001 , vol. 54, # 9 p. 703 - 709

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Citation Number: 9

Abstract

New cytokine production inhibitors, CJ-14, 877 (I) and CJ-14, 897 (II), were isolated from the fermentation broth of a basidiomycete, Marasmiellus sp. CL21624. Their structures were determined to be methyl-(7R, 8S)-5-(7, 8-dihydroxypropyl) pyridine-2-carboxylate and methyl (7R, 8S)-5-(8-acetoxy-7-hydroxypropyl) pyridme-2-carboxylate, respectively, by spectroscopic analyses. These compounds showed inhibitory activities for ...

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