Novel method for generation of secondary organozinc reagent: application to tandem carbon-carbon bond formation reaction of 1, 1-dibromoalkane

T Harada, Y Kotani, T Katsuhira, A Oku

Index: Harada, Toshiro; Kotani, Yasuo; Katsuhira, Takeshi; Oku, Akira Tetrahedron Letters, 1991 , vol. 32, # 12 p. 1573 - 1576

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Citation Number: 48

Abstract

Reaction of 1,1-dibromoalkane (R 1 CHBr 2 ) with trialkylzincate ((R 2 ) 3 ZnLi) followed by a palladium catalyzed coupling reaction of the resulting secondary organozinc reagent (R 1 CH(R 2 )ZnL) with various electrophiles (El-X) afforded R 1 CH(R 2 )El. ... J. Am. Chem. Soc., 111 (1989), p. 4028 and references cited therein. ... Tetrahedron Lett., 30 (1989), p. 3955 and references cited therein. ... Zincate (R 3 ZnLi) was prepared by the reaction of ...