Tetrahedron letters

Synthesis of a conformationally restricted dipeptide analogue and its evaluation as a β-turn mimic

…, FJR Rombouts, EV Van der Eycken, SM Toppet…

Index: De Borggraeve, Wim M.; Rombouts, Frederik J.R.; Van der Eycken, Erik V.; Toppet, Suzanne M.; Hoornaert, Georges J Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5693 - 5695

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Citation Number: 40

Abstract

The β-turn is one of the three major motifs of peptide and protein secondary structure. It plays a key role in many molecular recognition events including interactions between antigens and antibodies, peptide hormones and their receptors, and enzymes and their corresponding substrates. 1., and Due to the often poor bioavailability and low stability of natural peptide therapeutics, much effort has been devoted to the synthesis of peptide mimics to ...