Tetrahedron letters

Synthesis of L-2, 3, 5, 6-tetrafluoro-4-(phosphonomethyl) phenylalanine, a novel non-hydrolyzable phosphotyrosine mimetic and L-4-(phosphonodifluoromethyl) …

WQ Liu, BP Roques, C Garbay

Index: Liu, Wang-Qing; Roques, Bernard P.; Garbay, Christiane Tetrahedron Letters, 1997 , vol. 38, # 8 p. 1389 - 1392

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Citation Number: 18

Abstract

A new non-hydrolyzable phosphotyrosine analogue, L-F4Pmp and its N-Fmoc protected derivative were prepared by using an enantioselective synthetic pathway with camphor sultam as chiral auxiliary. The side chain pKa2 (6.9) of L-F4Pmp was determined. A new synthesis of L-F2Pmp was also described.

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