Hydrotrope: green and rapid approach for the catalyst-free synthesis of pyrazole derivatives

M Barge, S Kamble, A Kumbhar, G Rashinkar…

Index: Barge, Madhuri; Kamble, Santosh; Kumbhar, Arjun; Rashinkar, Gajanan; Salunkhe, Rajashri Monatshefte fur Chemie, 2013 , vol. 144, # 8 p. 1213 - 1218

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Citation Number: 3

Abstract

Abstract An efficient synthesis of pyrazole derivatives by condensation of 1, 3-diketone and hydrazines/hydrazides has been achieved in aqueous hydrotropic solution under catalyst- free conditions within a very short time. The present protocol is beneficial as it includes mild reaction conditions, shorter reaction times, use of universal solvent water, which avoids volatile organic solvents, high yields of products, and being environmentally friendly. ...