Simple Synthesis of Amides and Weinreb Amides Using PPh3 or Polymer??Supported PPh3 and Iodine
…, HK Akula, MK Lakshman
Index: Kumar, Amit; Akula, Hari Kiran; Lakshman, Mahesh K. European Journal of Organic Chemistry, 2010 , # 14 p. 2709 - 2715
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Citation Number: 17
Abstract
Abstract The combination of PPh 3/I 2 has been shown to be effective for the conversion of a range of carboxylic acids into secondary, tertiary, and Weinreb amides. Simplification of the procedure was possible with the use of polymer-supported PPh 3/I 2. Weinreb amides produced with the use of polymer-supported PPh 3 could be filtered through a short silica gel plug and used in further transformations. Thus, the use of polymer-supported PPh 3 ...
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