Total synthesis of spatol and other spatane diterpenes

…, B Basu, S Roy, ND Sachinvala

Index: Salomon; Basu; Roy; Sachinvala Journal of the American Chemical Society, 1991 , vol. 113, # 8 p. 3096 - 3106

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Citation Number: 26

Abstract

Abstract: Total syntheses of three spatane diterpenes stoechospermol (I), 5 (R), 15 (R), 18- trihydroxyspata-l3, 16 (E)-diene (2), and (+)-spat01 (3) were accomplished from a common intermediate, diol 7. The total synthesis established as R the absolute configuration at the 15- position in 2. Novel stereospecific transformations of 2, 3-epoxy-1, Cdiols into vicinal diepoxides were demonstrated and exploited for assembling the sensitive allylic ...