Biscoumarin: new class of urease inhibitors; economical synthesis and activity

…, S Iqbal, MA Lodhi, GM Maharvi, MI Choudhary…

Index: Khan, Khalid Mohammed; Iqbal, Sajid; Lodhi, Muhammad Arif; Maharvi, Ghulam Murtaza; Zia-Ullah; Choudhary, Muhammad Iqbal; Atta-ur-Rahman; Perveen, Shahnaz Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1963 - 1968

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Citation Number: 122

Abstract

A variety of biscoumarins (1–21) with variable substituents at C-11 were synthesized with an improved method and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 15.06–91.35 μM. The size and electron donating or withdrawing effects of substituents influenced the activity, which lead to the urease inhibitors.