A convergent synthesis of (17R, 5Z, 8Z, 11Z, 14Z)-17-hydroxyeicosa-5, 8, 11, 14-tetraenoic acid analogues and their tritiated derivatives
…, VP Shevchenko, EA Rozhkova, MA Maslov, NV Groza…
Index: Ivanov, Igor V.; Romanov, Stepan G.; Shevchenko, Valery P.; Rozhkova, Elena A.; Maslov, Mikhail A.; Groza, Nataliya V.; Myasoedov, Nikolai F.; Kuhn, Hartmut; Myagkova, Galina I. Tetrahedron, 2003 , vol. 59, # 41 p. 8091 - 8097
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Citation Number: 8
Abstract
17 (R)-OH-AA and 14, 15-dehydro-17 (R)-OH-AA were synthesized from a common tetraacetylenic precursor and their azide derivatives were obtained in moderate yields via the corresponding p-toluenesulfonates. Since the azido group remained stable during tritiation procedure on Lindlar's catalyst in benzene, both 14, 15-dehydro-17 (S)-N3-AA and 14, 15-dehydro-17 (R)-OH-AA constitute useful intermediates in the synthesis of radio- ...