Solid-state NMR of N-acylureas derived from the reaction of hyaluronic acid with isotopically-labeled carbodiimides

…, JW Kuo, GS Harbison, GD Prestwich

Index: Pouyani, Tara; Kuo, Jing-Wen; Harbison, Gerard S.; Prestwich, Glenn D. Journal of the American Chemical Society, 1992 , vol. 114, # 15 p. 5972 - 5976

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Citation Number: 51

Abstract

Abstract: Hyaluronic acid (HA) is a naturally-occurring linear polysaccharide consisting of alternating D-glucuronic acid and N-acetyl-o-glucosamine residues. Reaction of the carboxyl group of the glucuronate residues with 1-ethyl-3-(3-(di-methy1amino) propyl) carbodiimide (EDC) in the presence of primary amines yielded only the N-acylurea adducts rather than the expected amide coupling products. To determine the nature of this linkage ...

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