20-Hydroxyeicosatetraenoic acid (20-HETE): structural determinants for renal vasoconstriction

…, M Alonso-Galicia, CW Sun, RJ Roman, N Ono…

Index: Yu, Ming; Alonso-Galicia, Magdalena; Sun, Cheng-Wen; Roman, Richard J.; Ono, Naoya; Hirano, Hitomi; Ishimoto, Tsuyoshi; Reddy, Y. Krishna; Katipally, Kishta Reddy; Reddy, Komandla Malla; Gopal, V. Raj; et al. Bioorganic & Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2802 - 2822

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Citation Number: 26

Abstract

The effects of natural and synthetic eicosanoids on the diameter of rat interlobular arteries studied in vitro were compared to that of the potent, endogenous vasoconstrictor 20-HETE. Vasoconstrictor activity was optimum for chain lengths of 20-22 carbons with at least one olefin or epoxide between located between C (13)-C (15) and an oxygen substituent at C (20)-C (22). The presence of Δ (Zou et al. Am. J. Physiol. 1996, 270, R228; Gebremedhin, ...

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