Tetrahedron letters

Microwave-assisted solid-phase Dötz benzannulation reaction: a facile synthesis of 2, 3-disubstituted-1, 4-naphthoquinones

M Shanmugasundaram, I Garcia-Martinez, Q Li…

Index: Shanmugasundaram, Muthian; Garcia-Martinez, Israel; Li, Qingyi; Estrada, Abril; Martinez, Nancy E.; Martinez, Luis E. Tetrahedron Letters, 2005 , vol. 46, # 44 p. 7545 - 7548

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Citation Number: 19

Abstract

A microwave-assisted solid-supported Dötz benzannulation of chromium carbene complexes with various alkynes has been developed. The oxidative cleavage of the resulting resin-bound 1, 4-naphthols affords 2, 3-disubstituted-1, 4-naphthoquinone derivatives in good to moderate yields with high purities.

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