The Formal Total Synthesis of FR252921–An Immunosuppressant

JS Yadav, S Sengupta

Index: Yadav; Sengupta, Sandip European Journal of Organic Chemistry, 2013 , # 2 p. 376 - 388

Full Text: HTML

Citation Number: 4

Abstract

Abstract The formal total synthesis of FR252921 is described. The key steps include the preparation of three fragments starting from 1, 4-butanediol,(R)-malic acid, and prenol, respectively, followed by two consecutive peptide couplings of the three fragments. Other key steps involve an allene-type rearrangement or enyne isomerization to install the triene moiety, a Seebach methylation, a Julia olefination to construct the trisubstituted diene unit, ...

Related Articles:

Intramolecular formal oxa-[3+ 3] cycloaddition approach to the ABD system of phomactin A

[Cole, Kevin P.; Hsung, Richard P. Organic Letters, 2003 , vol. 5, # 25 p. 4843 - 4846]

An Efficient Total Synthesis of (2E, 4E, 7R)??Farnesa??2, 4, 10??triene from (R)??(+)??Citronellal

[Li, Jing; Liu, Zuosheng; Lan, Jiong; Li, Yulin Journal of the Chinese Chemical Society, 1999 , vol. 46, # 2 p. 259 - 262]

More Articles...