Tetrahedron letters

Direct Leuckart-type reductive amination of aldehydes and ketones: a facile one-pot protocol for the preparation of secondary and tertiary amines

D O'Connor, A Lauria, SP Bondi, S Saba

Index: O'Connor, Danielle; Lauria, Ashley; Bondi, Steven P.; Saba, Shahrokh Tetrahedron Letters, 2011 , vol. 52, # 1 p. 129 - 132

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Citation Number: 23

Abstract

An alternative DRA approach for the preparation of amines is the Leuckart reaction, 10 whereby an aldehyde or a ketone is heated in the presence of ammonium formate 11 or formamide, 12 or mixtures of formamide and formic acid. 13 and 14 The product of the Leuckart reaction is often the formyl derivative of the desired amine, 11, 12 and 13 which must be hydrolyzed with acid. This requirement makes the Leuckart reaction unsuitable for substrates with acid- ...

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