Oxadiazoles in medicinal chemistry

J Boström, A Hogner, A Llinàs, E Wellner…

Index: Bostroem, Jonas; Hogner, Anders; Llinas, Antonio; Wellner, Eric; Plowright, Alleyn T. Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1817 - 1830

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Citation Number: 167

Abstract

Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms. Oxadiazoles are frequently occurring motifs in druglike molecules, and they are often used with the intention of being bioisosteric replacements for ester and amide functionalities. The current study presents a systematic comparison of 1, 2, 4-and 1, 3, 4-oxadiazole matched pairs in the ...

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