Steroids

A facile synthesis of 5β-cholestane-3α, 7α, 12α, 25-tetrol

B Dayal, E Bagan, J Speck, G Salen

Index: Dayal, B.; Bagan, E.; Speck, J.; Salen, G. Steroids, 1980 , vol. 35, # 4 p. 439 - 444

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Citation Number: 4

Abstract

Abstract A convenient procedure for the synthesis of 5β-cholestane-3α, 7α, 12α, 25-tetrol via a modified homologation sequence of the intermediate 3α, 7α, 12α-triformyloxy-24-oxo-25- diazo-25-homo-5β-cholane involving a homogeneous medium is described. This involves treating the intermediate α-diazoketone in methanol with a solution of silver benzoate in triethylamine. Grignard reaction of the resulting triformyloxy methyl homocholate yielded ...

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