Dinuclear copper (II) complexes that promote hydrolysis of GpppG, a model for the 5′-cap of mRNA

KP McCue, DA Voss, DA Voss Jr, C Marks…

Index: McCue, Kevin P.; Voss Jr., David A.; Marks, Christian; Morrow, Janet R. Journal of the Chemical Society - Dalton Transactions, 1998 , # 18 p. 2961 - 2963

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Citation Number: 28

Abstract

The hydrolysis of the monoribonucleotide GpppG, a model compound for the 5′-cap structure of mRNA, by dinuclear Cu (II) complexes of triazacyclononane was 100-fold more rapid than in the presense of the analogous mononuclear complex; a first-order or second- order dependence on the catalyst was observed for two different dinuclear complexes.