Synthetic Communications

An expedient stereocontrolled synthesis of 7-cis-retinoids

R Alvarez, B Domínguez, AR de Lera

Index: Alvarez; Dominguez; De Lera Synthetic Communications, 2001 , vol. 31, # 13 p. 2083 - 2087

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Citation Number: 5

Abstract

Ethyl (7 Z)–retinoate 5 has been efficiently synthesized using as keystep the Suzuki coupling of an in situ generated alkenylboronic acid and the geometrically homogeneous tetraenyliodide with (Z)-geometry, itself obtained by yodomethylenation according to Stork's