Synthesis of 2-aminoazulene derivatives. Nucleophilic and palladium-catalyzed amination of 2-substituted azulene

R Yokoyama, S Ito, T Okujima, T Kubo, M Yasunami…

Index: Yokoyama, Ryuji; Ito, Shunji; Okujima, Tetsuo; Kubo, Takahiro; Yasunami, Masafumi; Tajiri, Akio; Morita, Noboru Tetrahedron, 2003 , vol. 59, # 41 p. 8191 - 8198

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Citation Number: 14

Abstract

Amination of 2-substituted azulene was carefully examined using several types of amines, and the scope and limitation of substrates and reagents in these direct nucleophilic aminations were found. The synthesis of 2-aminoazulenes was successfully achieved by the reaction of 2-bromoazulene with several amines via palladium-catalyzed amination.