Catalytic Asymmetric Synthesis of Spirocyclic Azlactones by a Double Michael??Addition Approach

M Weber, W Frey, R Peters

Index: Weber, Manuel; Frey, Wolfgang; Peters, Rene Chemistry - A European Journal, 2013 , vol. 19, # 25 p. 8342 - 8351

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Citation Number: 32

Abstract

Abstract Spirocyclic azlactones are shown to be useful precursors of cyclic quaternary amino acids, such as the constrained cyclohexane analogues of phenylalanine. These compounds are of interest as building blocks for the synthesis of artificial peptide analogues with controlled folds in the peptide backbone. They were prepared in the present study by a step- and atom-economic catalytic asymmetric tandem approach, requiring two steps starting ...