Meldrum's acids as acylating agents in the catalytic intramolecular Friedel-Crafts reaction

E Fillion, D Fishlock, A Wilsily…

Index: Fillion, Eric; Fishlock, Dan; Wilsily, Ashraf; Goll, Julie M. Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1316 - 1327

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Citation Number: 142

Abstract

The intramolecular Friedel-Crafts acylation of aromatics with Meldrum's acid derivatives catalyzed by metal trifluoromethanesulfonates is reported. Meldrum's acids are easily prepared, functionalized, handled, and purified. The synthesis of polysubstituted 1- indanones from benzyl Meldrum's acids was investigated thoroughly, and it was shown that a variety of catalysts were effective, while accommodating a diversity of functional groups ...