Recurrence of carboxylic acid-pyridine supramolecular synthon in the crystal structures of some pyrazinecarboxylic acids

P Vishweshwar, A Nangia…

Index: Vishweshwar, Peddy; Nangia, Ashwini; Lynch, Vincent M. Journal of Organic Chemistry, 2002 , vol. 67, # 2 p. 556 - 565

Full Text: HTML

Citation Number: 196

Abstract

X-ray crystal structures of pyrazinic acid 1 and isomeric methylpyrazine carboxylic acids 2-4 are analyzed to examine the occurrence of carboxylic acid-pyridine supramolecular synthon V in these heterocyclic acids. Synthon V, assembled by (carboxyl) OH⊙⊙⊙ N (pyridine) and (pyridine) CH⊙⊙⊙ O (carbonyl) hydrogen bonds, controls self-assembly in the crystal structures of pyridine and pyrazine monocarboxylic acids. The recurrence of acid-pyridine ...